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KMID : 0877220090130010015
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Journal of Korean Epilepsy Society
2009 Volume.13 No. 1 p.15 ~ p.18
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Cefepime-Induced Reversible Encephalopathy with Triphasic Waves in Patients with Impaired Renal Function
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Ryu Jeong-Am
Lee Seon-Min
Kim Jae-Il
Lee Geun-Ho
Lee Chang-Min
Song Young-Mok
Kim Jee-Hyun
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Abstract
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Cefepime is a widely used beta-lactam antibiotic. We first report two cases of cefepime-induced reversible encephalpathy in Korea. Two patients with renal impairment presented stupor while being treated with cefepime for pneumonia, one of whom also developed myoclonus and asterixis. Their electroencephalogram showed triphasic waves despite of normal liver function. After discontinuation of cefepime, they completely recovered with normalization of electroencephalogram. Early recognition of cefepime-induced encephalopathy and immediate withdrawal of cefepime would be important for the prognosis of the patients.
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KEYWORD
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Cefepime, Encephalopathy, Triphasic wave
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